기록과 전승:시간 위에 지성을 쌓다

Lupus Nephritis Abbreviation LN Disease Category Systemic autoimmune disease Affected Organ(s) Kidney Epidemiology ~35% SLE patients~10%에서 ESRD로 진행 Risk of Renal Failure 흑인, 남성, 소아 발병, 잦은 재발, 불완전 관해, 고단백뇨 Pathogenesis Immune complex mediated nephritis Hallmark Clinical Features Proteinuria (0.5g/day) Hallmark Laboratory Findings 조직학 – Full house pattern (IgG, IgA, IgM + C3, C1q…

최초 작성: 2026.05.25 — Harrison’s Principles of Internal Medicine, 22nd ed. Introduction Definition 만성 염증성 질환. 대칭성·미란성 다발관절염(symmetric, erosive polyarthritis)을 특징으로 하며, 만성 염증성 관절염 중 가장 흔한 형태.1 Systemic disease — 관절 외 침범: 피로, 피하결절(subcutaneous nodules), 폐 침범, 심낭염(pericarditis), 말초신경병증(peripheral neuropathy), 혈관염(vasculitis), 혈액학적 이상.1 Clinical Significance Contemporary Paradigm Shift Clinical Features Onset &…

Antiphospholipid Syndrome Abbreviation APS Disease Category Systemic autoimmune disease Affected Organ(s) Epidemiology 40-50/100,000젊은 여성 호발SLE 1/3에서 aPL 양성, 그 중 10-15%가 APS로 진행. Risk Factors Pathogenesis aPL이 손상된 내피세포에 결합하여 염증 및 혈전 생성.` Hallmark Clinical Features Recurrent venous thrombosisRecurrent arterial thrombosisRecurrent pregnancy lossPreeclampsia / placental insufficiencyThrombocytopeniaLivedo reticularis Hallmark Laboratory Findings aPL– Lupus anticoagulant– Anticardiolipin…

Systemic Lupus Erythematosus Abbreviation SLE Disease Category Systemic autoimmune disease Affected Organ(s) Skin, Joints, Kidneys, CNS, Serosa, Hematologic system … Epidemiology Female : Male ≈ 9 : 1 Risk Factors Pathogenesis Autoantibody-mediated immune complex deposition with complement activation. Hallmark Clinical Features DOPAMIN RASH • Discoid rash • Oral ulcer • Photosensitivity • Arthritis • Malar…